Ozone Therapy is the treatment of some diseases by using Medical Ozone gas (3-5% O3 - 95% O2).
Obtaining Medical Ozone
O3 gas; Devices called 'Medical Ozone Generator' are also obtained in an environment where a certain flow rate and 99.9%-100% pure medical oxygen is subjected to high electrical voltage. If normal air is used in ozone production, toxic N2 O2 (nitrogen dioxide) occurs due to the high nitrogen content, therefore it is not recommended.
All types of Ozone application can be successfully performed in our clinic:
Major Autohemotherapy (Patient's own blood ozonation and intravenous administration), Rectal Ozone application, Minor Autohemotherapy (Patients' own blood ozonation and intramuscular application) and Local Ozone gas application.
How Is Ozone Formed?
Ozone, which is in the stratosphere layer in the atmosphere, is formed on the one hand by the effect of ultraviolet radiation, and on the other hand is destroyed. This process occurs at different frequencies of ultraviolet radiation. 1 While the presence of ozone in the stratosphere is vital because it blocks ultraviolet B and C rays from the sun, its presence in the troposphere, the layer of air we live in, is very dangerous for the respiratory tract and is considered air pollution. 2 Ozone Therapy; It is the treatment of some diseases by using medical ozone gas (3-5% O3 - 95% O2) gas.
Mechanism of action of medical ozone
Medical ozone has well-known bactericidal (bactericidal), fungicidal (fungicide) and virostatic (inhibiting virus proliferation) properties. Therefore, it is used for disinfection of infected wounds and also for the treatment of diseases caused by bacteria and viruses.
Its ability to increase blood circulation is used in the treatment of circulatory disorders.
In low doses, it increases the body's resistance
We can do ozone application for the following ailments:
Application methods
Medical Ozone Generators
Only 3% to 5% of this gas coming out of the generator consists of ozone, the rest is oxygen. O3 - Unstable, unstable molecule Since O3 is an unstable molecule, it enters chemical reactions more easily. It is more effective in creating a biological response. O3 is called active superoxygen because of its effects.
Liquids for Medical Purposes We Can Dissolve Ozone
O3 dissolves in liquids like other gases according to Henry's Law. Its dissolution depends on:
Why Ozone Instead of Oxygen?
Oxygen is a more stable element than O3. The solubility of O3 in biological fluids is 10 times higher than that of oxygen. Therefore, the risk of embolism is less than oxygen. One of the most ideal solvents for O3 is oxygen.
Ozonoid Formation
Due to its unstability, O3 molecules react with each other or with other atom-molecules within seconds and turn into more stable O2 and OX (Ozonoid) molecules. O3 is no longer gaseous once it is applied to the body or any Medical Ozone Generator 0025 environment. In other words, there is no ozone gas in the body anymore.4,5 OX (Ozonoid) molecules turn into ROS and LOPs.
Free Radicals (SR) are reactive substances that can be the initiator of various pathological processes, can be involved in intermediate steps, or can occur as a result. They can also occur in various physiological conditions such as respiratory explosion in mitochondria and phagocytes during aerobic respiration in the organism.
Oxidation Effect
O3 enters into oxidation reaction with all organic-inorganic compounds. It reacts with lipids (on the cell membrane, atherosclerotic plaque, etc.) and breaks the cell membrane, showing antimicrobial disinfection (it is a disinfectant 3125 times stronger than chlorine) on microorganisms (Herpes, HCV, HIV, Gr.Positive bacteria, etc.). It also shows anti-tumoral effect on tumor cell. It can neutralize toxins by oxidizing them.11,12 Bocci names ozone therapy as “Therapeutic Shock - Acute Oxidative Stress” because of some physiological and biochemical reactions. We can say that the essence of ozone therapy is "controlled oxidative stress" given to the body. 13 Tumor cells have “anaerobic metabolism”. When O3 gas is used directly, it oxidizes the outer lipid layer of malignant cells and lysis. Since tumor cells have a primitive life form, they have not been able to develop antioxidant systems (AOS) mechanisms that can protect themselves against oxidation. O3 therapy can be used in conjunction with conventional treatments for cancer.
For the last 20 years, the existence of “hypoxic cells” in human tumors has been indirectly proven. It is known that in experimental animal tumors, the presence of cells resistant to treatment - radiation - 0026 due to tissue hypoxia is known, and it is known that anemia in radiotherapy is one of the important bad prognostic factors. It has been shown that arterial oxygen content and hemoglobin levels are important prognostic factors in the evaluation of the tumor's response to radiation and are directly proportional to the growth delay in tumor tissue.14 O3 increases the radiochemobiological sensitizing effects by increasing tissue oxygenation and SR neutralization in the tissues. Tumor responses to chemotherapy (CT) have also been shown to contribute negatively to hypoxic cells. O3 therapy reduces side effects in cancer treatment; O3 therapy increases the leukocyte count. (reduces symptoms of bone marrow suppression due to chemotherapy and radiotherapy). O3 therapy prevents radiochemotherapy-induced fibrosis, vascular changes and polyneuropathies, activates AOS and reduces the SR and oxidative stress effects of chemotherapy and radiotherapy. O3 therapy increases energy production and improves performance-general condition. When O3 gas is applied directly on the tumor, it causes the cell membrane to break down with the oxidation effect. O3 therapy, eliminating hypoxia; It has an inhibitory effect on tumor angiogenesis. Also, O3 therapy activates the immune system.
Major Autohemotherapy (MAHT) as a Biological Effect Model
During MAHT, O3 dissolves rapidly in plasma. Some of the O3 is reduced by the antioxidants in the plasma. This sequence also occurs in ROS. The half-life of ROS is as short as seconds. Even before the blood is transfused back to the patient, these disappear and are replaced by oxidizing LOPs products such as H2 O2 formed by the oxyBagging Ozone Application Major Ozone Autohemotherapy Application Local Ozone Application Minor Autohemotherapy Application 0027 dation of the cell membranes.
Enzymatic-Noenzymatic Antioxidation System
a. Non-enzymatic AOS: Uric acid, ascorbic acid, protein (especially albumin), non-protein thiols, vitamin E and bilirubin.
b. Enzymatic AOS: From superoxide dismutase (SOD), catalase (CAT) to glutathione peroxidase (GPx) glutathione transferase (GST), glutathione (GSH) and glutathione reductase (GR).
Oxidation-Disinfectant Effect
Ozone has a strong oxidation-forming ability. Therefore, in the use of high concentration O3 gas LOCAL-EXTERNAL, Oxygen with OXIDATION is a more stable element than O3. The solubility of O3 in biological fluids is 10 times higher than that of oxygen. Therefore, the risk of embolism is less than oxygen. One of the most ideal solvents for O3 is oxygen. It is BACTERICIDAL, VIRICIDAL and FUNGIIDAL effective. Since cells of multicellular organisms have AOS, O3 does not have a damaging or irritating effect on tissues. Although ozone is an agent with a high disinfectant effect, ozone does not have such an effect in vivo.
Blood;
Ozonized SF;
Antioxidant System Dose
Normally, ozone therapy is applied twice a week. However, it has been reported that it is done every day, even 3 times a day, and there is no problem. The volume of blood to be ozonated should not exceed 300 mL, especially in elderly and ill-constituted patients.
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